Medicine

Progressing ASO treatments coming from development to application

.Competing enthusiasms.R.S., M.S., H.G. and also A.A.R. are actually coordinators of the 1M1M initiative. H.G. and also A.A.R. are actually panel of supervisors participants and also R.S., M.S. and also A.A.R. are actually participants of the clinical advising board of N1C. A.A.R. discloses job through LUMC, which possesses patents on exon-skipping modern technology, a number of which has been certified to BioMarin and also subsequently sublicensed to Sarepta. As co-inventor of some of these patents, A.A.R. was actually qualified to a reveal of nobilities. A.A.R. even further divulges working as specialist for PTC Therapies, Sarepta Therapeutics, Regenxbio, Dyne Therapies, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco as well as Astra Zeneca. Over the last 5 years, A.A.R. also executed ad hoc consulting with for Alpha Anomeric. A.A.R. also states subscription of the scientific boards of advisers of Eisai, Hybridize Therapies, Silence Therapies, Sarepta Rehabs, Sapreme as well as Mitorx. Before 5 years, A.A.R. was additionally a clinical advisory board member for ProQR. Wage for A.A.R. u00e2 s consulting and also suggesting activities is paid to LUMC. Over the last 5 years, LUMC also got audio speaker gratuity from PTC Therapeutics, Alnylam Netherlands, Italfarmaco and also Pfizer as well as moneying for arrangement analysis coming from Sapreme, Eisai, Galapagos, Synaffix and Alpha Anomeric. Venture financing is actually obtained from Sarepta Therapies and also Entrada using unrestricted gives. H.G. possesses absolutely nothing to disclose relative to the subject matters covered in this particular document. Previously 5 years, he has actually also acquired consultancy gratuity coming from UCB. M.S. got working as a consultant gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and Solaxa in the past 5 years, all irrelevant to the present document. R.S. has nothing to make known in regard to the subject matters covered in this document. She has actually gotten audio speaker and/or working as a consultant honoraria or even financing contributions from Abbvie, Bial, STADA and also Everpharma in the past 5 years.